The Human Cytomegalovirus Major Immediate-Early Proteins as Antagonists of Intrinsic and Innate Antiviral Host Responses

The Human Cytomegalovirus Major Immediate-Early Proteins as Antagonists of Intrinsic and Innate Antiviral Host Responses

Blog Article

The major immediate-early (IE) gene of human cytomegalovirus (CMV) is believed to have a decisive role in acute infection and its activity is an important indicator of viral reactivation from latency.Although a variety of gene products are expressed from this region, the Rugby Shirt 72-kDa IE1 and the 86-kDa IE2 nuclear phosphoproteins are the most abundant and important.Both proteins have long been recognized as promiscuous transcriptional regulators.More recently, a critical role of the IE1 and IE2 proteins in counteracting nonadaptive SPORT BODY SPRAY host cell defense mechanisms has been revealed.

In this review we will briefly summarize the available literature on IE1- and IE2-dependent mechanisms contributing to CMV evasion from intrinsic and innate immune responses.